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Predictive Analysis of Dementia

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Biomarker-based (molecular + immune)
Korean-style integrated dementia early diagnosis technology research

We are researching and developing an integrated diagnostic service model for Alzheimer's disease dementia and vascular dementia with biomarker-based diagnostic technology for mild cognitive impairment (MCI) and silent brain infraction (SBI). There is.
It is a planned (designed) bio-based testing technique that can change the paradigm of early dementia screening, and effective early diagnosis close to Korean needs is defined quickly and easily.
KGIC's 'Korean Integrated Dementia Early Screening Project' is a real expert in business unit research and development.

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  • MCI-K™
  • It is a major protein of HDL and plays a role in transporting Aβ from brain/CSF to blood by binding to Aβ, and blocking the aggregation of Aβ binding ApoA1 and Aβ, which plays a role in relieving inflammation in nerve cells, inhibiting the neurotoxicity of Aβ in AD patients In TTR, which has been reported to have a significantly low TTR concentration in the study, Aβ, which is involved in immunity and accumulates in proinflammatory responders, is removed by phagocytosis by activating glial cells, or inhibition of plaque formation (lower C3 concentration = Aβ brain accumulation and inflammation of nerve cells) A study of Korean MCI analysis technique using markers of C3 complement protein.
  • SBI-K™
  • As a kind of aldehyde, it produces lipid peroxidation in the human body, induces the production of acrolein and inflammatory cytokines, which are reported to be useful as markers for atherosclerosis, renal failure, and stroke, and induces the production of IL-6 and IL-8. IL-6, a pentameric protein found in plasma, which is involved in acute ischemic stroke and plays an important role in the progression of symptoms, increases the concentration of CRP as IL-6 is secreted by macrophages and T cells. A study on Korean-style SBI analysis techniques using CRP markers, which were important in predicting the degree of brain damage and blood vessel damage.
2021 MCI-K ™ Psychiatric Hospital conducted clinical trials, Pusan National University

2021 MCI-K ™, Inje University Busan Paik Hospital neurologist conducted clinical trials

SBI-K™ clinical trial in preparation in 2021

Early diagnosis of AD type MCI
MCI-K™

A specific diagnostic technology for Korean Alzheimer's-type mild cognitive impairment, including a non-Alzheimer's-type (Aβ-PET(-)) mild cognitive impairment control group, and stipulates a clear standard for NDC where there may be some deposition of Aβ, which is the pathophysiology of Alzheimer's type dementia in NDC. Research and clinical trials are ongoing.

Biomarker
Apolipoprotein A-I

Measured using automated equipment (Hitach, AUTOMATIC ANALYZER MODEL 7020) by Turbidimetric immunoassay (TIA) using a commercial kit (Sekisui).

Biomarker
Transthyretin

Measured using automated equipment (Hitach, AUTOMATIC ANALYZER MODEL 7020) by Turbidimetric immunoassay (TIA) using a commercial kit (Nittobo).

Biomarker
C3

nC3 antibody (Capture, Detection) was measured by ELISA (enzyme-linked immunosorbent assay) method provided by MCBI.

Early diagnosis of VD type SBI
SBI-K™

IL6, hs-CRP, Acro protein markers Evaluated using ROC (Receiver operating characteristic) curve, and NEUROSIM/L software (Including factor_Age) are analyzed to analyze specific diagnostic technology for asymptomatic stroke and clinical trials are underway.

Biomarker
Acrolein

Polyamine oxidase (PAO)
Polyamines play an important role in cell growth and viability
When cells are damaged, polyamines are broken down into toxic compounds (acrolein) and H2O2.
More toxic than the main reactive oxygen species ROS
Well-correlated with the severity (renal failure, stroke)
Reported usefulness as a biomarker for stroke

Biomarker
IL-6 (Interleukine 6)

Acts as pro-inflammatory cytokine
Capable of crossing the blood-brain barrier

Biomarker
CRP (C-reactive protein)

Produced by the liver and secreted into the bloodstream
Increased in inflammation and infection, myocardial infarction, after surgery and trauma
One of several proteins called acute phase reactants
Monitoring changes in inflammation associated with several infectious and autoimmune diseases

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